Journal of Medicinal Chemistry
Volume 43, Issue 24 (November 30, 2000)
Copyright © 2000 American Chemical Society

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LETTERS

4575-4578

Discovery of Chiral N,N-Disubstituted Trifluoro-3-amino-2-propanols as Potent Inhibitors of Cholesteryl Ester Transfer Protein Richard C. Durley, Margaret L. Grapperhaus, Mark A. Massa, Deborah A. Mischke, Barry L. Parnas, Yvette M. Fobian, Nigam P. Rath, Dorothy D. Honda, Ming Zeng, Daniel T. Connolly, Deborah M. Heuvelman, Bryan J. Witherbee, Kevin C. Glenn, Elaine S. Krul, Mark E. Smith, and James A. Sikorski [Full Article - PDF]

4579-4581

Analogues of Bacteriocins: Antimicrobial Specificity and Interactions of Leucocin A with Its Enantiomer, Carnobacteriocin B2, and Truncated Derivatives Liang Z. Yan, Alan C. Gibbs, Michael E. Stiles, David S. Wishart, and John C. Vederas [Full Article - PDF]

ARTICLES

4582-4593

1,3-Diaryl-4,5,6,7-tetrahydro-2H-isoindole Derivatives: A New Series of Potent and Selective COX-2 Inhibitors in Which a Sulfonyl Group Is Not a Structural Requisite Bernard Portevin, Charles Tordjman, Philippe Pastoureau, Jacqueline Bonnet, and Guillaume De Nanteuil [Full Article - PDF]

4594-4605

Simulations of the Estrogen Receptor Ligand-Binding Domain: Affinity of Natural Ligands and Xenoestrogens B. Chris Oostenbrink, Jed W. Pitera, Marola M. H. van Lipzig, John H. N. Meerman, and Wilfred F. van Gunsteren [Full Article - PDF]

4606-4616

Pyrido[2,3-d]pyrimidin-7-one Inhibitors of Cyclin-Dependent Kinases Mark Barvian, Diane H. Boschelli, Jennifer Cossrow, Ellen Dobrusin, Ali Fattaey, Alex Fritsch, David Fry, Patricia Harvey, Paul Keller, Michelle Garrett, Frances La, Wilbur Leopold, Dennis McNamara, Maire Quin, Susanne Trumpp-Kallmeyer, Peter Toogood, Zhipei Wu, and Erli Zhang [Full Article - PDF]

4617-4628

Cation Substitution in Cationic Phosphonolipids: A New Concept To Improve Transfection Activity and Decrease Cellular Toxicity Virginie Floch, Séverine Loisel, Erwann Guenin, Anne Cécile Hervé, Jean Claude Clément, Jean Jacques Yaouanc, Hervé des Abbayes, and Claude Férec [Full Article - PDF]

4629-4635

Chiral Derivatives of 2-Cyclohexylideneperhydro-4,7-methanoindenes, a Novel Class of Nonsteroidal Androgen Receptor Ligand: Synthesis, X-ray Analysis, and Biological Activity Peter M. Burden, Tu Hoa Ai, Hui Qiang Lin, Mualla Akinci, Michelle Costandi, Trevor M. Hambley, and Graham A. R. Johnston [Full Article - PDF]

4636-4646

7-Deazaadenines Bearing Polar Substituents: Structure-Activity Relationships of New A1 and A3 Adenosine Receptor Antagonists Sonja Hess, Christa E. Müller, Wolfram Frobenius, Ulrike Reith, Karl-Norbert Klotz, and Kurt Eger [Full Article - PDF]

4647-4656

5-Substituted N4-Hydroxy-2'-deoxycytidines and Their 5'-Monophosphates: Synthesis, Conformation, Interaction with Tumor Thymidylate Synthase, and in Vitro Antitumor Activity Krzysztof Felczak, Agnieszka Miazga, Jarosaw Poznaski, Maria Bretner, Tadeusz Kulikowski, Jolanta M. Dzik, Barbara Goos, Zbigniew Zieliski, Joanna Ciela, and Wojciech Rode [Full Article - PDF]

4657-4666

New Tacrine-Huperzine A Hybrids (Huprines): Highly Potent Tight-Binding Acetylcholinesterase Inhibitors of Interest for the Treatment of Alzheimer's Disease Pelayo Camps, Rachid El Achab, Jordi Morral, Diego Muñoz-Torrero, Albert Badia, Josep Eladi Baños, Nuria María Vivas, Xavier Barril, Modesto Orozco, and Francisco Javier Luque [Full Article - PDF]

4667-4677

4-Aminoquinolines: Novel Nociceptin Antagonists with Analgesic Activity Hisashi Shinkai, Takao Ito, Tetsuya Iida, Yuki Kitao, Hideki Yamada, and Itsuo Uchida [Full Article - PDF]

4678-4693

Conformationally Constrained Butyrophenones with Affinity for Dopamine (D1, D2, D4) and Serotonin (5-HT2A, 5-HT2B, 5-HT2C) Receptors: Synthesis of Aminomethylbenzo[b]furanones and Their Evaluation as Antipsychotics Enrique Raviña, Isabel Casariego, Christian F. Masaguer, José A. Fontenla, Gisela Y. Montenegro, María E. Rivas, M. Isabel Loza, Maria J. Enguix, Maria Villazon, M. Isabel Cadavid, and Gian C. Demontis [Full Article - PDF]

4694-4700

Adenosine Deaminase Inhibitors: Synthesis and Biological Evaluation of Unsaturated, Aromatic, and Oxo Derivatives of (+)-erythro-9-(2'S-Hydroxy-3'R-nonyl)adenine [(+)-EHNA] Palle V. P. Pragnacharyulu, Vaibhav Varkhedkar, Mark A. Curtis, I. F. Chang, and Elie Abushanab [Full Article - PDF]

4701-4710

Effect of Ring Fluorination on the Pharmacology of Hallucinogenic Tryptamines Joseph B. Blair, Deborah Kurrasch-Orbaugh, Danuta Marona-Lewicka, Medhane G. Cumbay, Val J. Watts, Eric L. Barker, and David E. Nichols [Full Article - PDF]

4711-4720

Formaldehyde-Induced Alkylation of a 2'-Aminoglucose Rebeccamycin Derivative to Both A·T and G·C Base Pairs in DNA Christian Bailly, Jean-François Goossens, William Laine, Fabrice Anizon, Michelle Prudhomme, Jinsong Ren, and Jonathan B. Chaires [Full Article - PDF]

BOOK REVIEWS

4721-4721

Chemists at War. Accounts of Chemical Research in the United States During World War II By William A. Remers. Clarice Publications, Tucson, AZ. 2000. 216 pp. 13.5 × 16 cm. ISBN 0-9677940-0-5. $14.95 (paperback). Edward R. Atkinson [Full Article - PDF]

4721-4722

Nucleic Acids: Structures, Properties, and Functions By Victor A. Bloomfield, Donald M. Crothers, and Ignacio Tinoco, Jr., with contributions from John E. Hearst, David E. Wemmer, Peter A. Kollman, and Douglas H. Turner. University Science Books, Sausalito, CA. 2000. ix + 794 pp. 17 × 25 cm. ISBN 0-935702-49-0. $85.00. Sean Michael Kerwin [Full Article - PDF]

ADDITIONS AND CORRECTIONS

4723-4723

QSAR Model for Drug Human Oral Bioavailability. Fumitaka Yoshida and John G. Topliss: [Full Article - PDF]

4724-4724

3,5-Disubstituted-4-hydroxyphenyls Linked to 3-Hydroxy-2-methyl-4(1H)-pyridinone: Potent Inhibitors of Lipid Peroxidation and Cell Toxicity. David Bebbington, Nathaniel J. T. Monck, Suneel Gaur, Alan M. Palmer, Karen Benwell, Victoria Harvey, Craig S. Malcolm, and Richard H. P. Porter: [Full Article - PDF]