LETTERS
|
4575-4578
Discovery of Chiral N,N-Disubstituted Trifluoro-3-amino-2-propanols as Potent Inhibitors of Cholesteryl Ester Transfer Protein
Richard C. Durley,
Margaret L. Grapperhaus,
Mark A. Massa,
Deborah A. Mischke,
Barry L. Parnas,
Yvette M. Fobian,
Nigam P. Rath,
Dorothy D. Honda,
Ming Zeng,
Daniel T. Connolly,
Deborah M. Heuvelman,
Bryan J. Witherbee,
Kevin C. Glenn,
Elaine S. Krul,
Mark E. Smith, and
James A. Sikorski
[Full Article -
PDF]
| |
4579-4581
Analogues of Bacteriocins: Antimicrobial Specificity and Interactions of Leucocin A with Its Enantiomer, Carnobacteriocin B2, and Truncated Derivatives
Liang Z. Yan,
Alan C. Gibbs,
Michael E. Stiles,
David S. Wishart, and
John C. Vederas
[Full Article -
PDF]
| |
ARTICLES
|
4582-4593
1,3-Diaryl-4,5,6,7-tetrahydro-2H-isoindole Derivatives: A New Series of Potent and Selective COX-2 Inhibitors in Which a Sulfonyl Group Is Not a Structural Requisite
Bernard Portevin,
Charles Tordjman,
Philippe Pastoureau,
Jacqueline Bonnet, and
Guillaume De Nanteuil
[Full Article -
PDF]
| |
4594-4605
Simulations of the Estrogen Receptor Ligand-Binding Domain: Affinity of Natural Ligands and Xenoestrogens
B. Chris Oostenbrink,
Jed W. Pitera,
Marola M. H. van Lipzig,
John H. N. Meerman, and
Wilfred F. van Gunsteren
[Full Article -
PDF]
| |
4606-4616
Pyrido[2,3-d]pyrimidin-7-one Inhibitors of Cyclin-Dependent Kinases
Mark Barvian,
Diane H. Boschelli,
Jennifer Cossrow,
Ellen Dobrusin,
Ali Fattaey,
Alex Fritsch,
David Fry,
Patricia Harvey,
Paul Keller,
Michelle Garrett,
Frances La,
Wilbur Leopold,
Dennis McNamara,
Maire Quin,
Susanne Trumpp-Kallmeyer,
Peter Toogood,
Zhipei Wu, and
Erli Zhang
[Full Article -
PDF]
| |
4617-4628
Cation Substitution in Cationic Phosphonolipids: A New Concept To Improve Transfection Activity and Decrease Cellular Toxicity
Virginie Floch,
Séverine Loisel,
Erwann Guenin,
Anne Cécile Hervé,
Jean Claude Clément,
Jean Jacques Yaouanc,
Hervé des Abbayes, and
Claude Férec
[Full Article -
PDF]
| |
4629-4635
Chiral Derivatives of 2-Cyclohexylideneperhydro-4,7-methanoindenes, a Novel Class of Nonsteroidal Androgen Receptor Ligand: Synthesis, X-ray Analysis, and Biological Activity
Peter M. Burden,
Tu Hoa Ai,
Hui Qiang Lin,
Mualla Akinci,
Michelle Costandi,
Trevor M. Hambley, and
Graham A. R. Johnston
[Full Article -
PDF]
| |
4636-4646
7-Deazaadenines Bearing Polar Substituents: Structure-Activity Relationships of New A1 and A3 Adenosine Receptor Antagonists
Sonja Hess,
Christa E. Müller,
Wolfram Frobenius,
Ulrike Reith,
Karl-Norbert Klotz, and
Kurt Eger
[Full Article -
PDF]
| |
4647-4656
5-Substituted N4-Hydroxy-2'-deoxycytidines and Their 5'-Monophosphates: Synthesis, Conformation, Interaction with Tumor Thymidylate Synthase, and in Vitro Antitumor Activity
Krzysztof Felczak,
Agnieszka Miazga,
Jarosaw Poznaski,
Maria Bretner,
Tadeusz Kulikowski,
Jolanta M. Dzik,
Barbara Goos,
Zbigniew Zieliski,
Joanna Ciela, and
Wojciech Rode
[Full Article -
PDF]
| |
4657-4666
New Tacrine-Huperzine A Hybrids (Huprines): Highly Potent Tight-Binding Acetylcholinesterase Inhibitors of Interest for the Treatment of Alzheimer's Disease
Pelayo Camps,
Rachid El Achab,
Jordi Morral,
Diego Muñoz-Torrero,
Albert Badia,
Josep Eladi Baños,
Nuria María Vivas,
Xavier Barril,
Modesto Orozco, and
Francisco Javier Luque
[Full Article -
PDF]
| |
4667-4677
4-Aminoquinolines: Novel Nociceptin Antagonists with Analgesic Activity
Hisashi Shinkai,
Takao Ito,
Tetsuya Iida,
Yuki Kitao,
Hideki Yamada, and
Itsuo Uchida
[Full Article -
PDF]
| |
4678-4693
Conformationally Constrained Butyrophenones with Affinity for Dopamine (D1, D2, D4) and Serotonin (5-HT2A, 5-HT2B, 5-HT2C) Receptors: Synthesis of Aminomethylbenzo[b]furanones and Their Evaluation as Antipsychotics
Enrique Raviña,
Isabel Casariego,
Christian F. Masaguer,
José A. Fontenla,
Gisela Y. Montenegro,
María E. Rivas,
M. Isabel Loza,
Maria J. Enguix,
Maria Villazon,
M. Isabel Cadavid, and
Gian C. Demontis
[Full Article -
PDF]
| |
4694-4700
Adenosine Deaminase Inhibitors: Synthesis and Biological Evaluation of Unsaturated, Aromatic, and Oxo Derivatives of (+)-erythro-9-(2'S-Hydroxy-3'R-nonyl)adenine [(+)-EHNA]
Palle V. P. Pragnacharyulu,
Vaibhav Varkhedkar,
Mark A. Curtis,
I. F. Chang, and
Elie Abushanab
[Full Article -
PDF]
| |
4701-4710
Effect of Ring Fluorination on the Pharmacology of Hallucinogenic Tryptamines
Joseph B. Blair,
Deborah Kurrasch-Orbaugh,
Danuta Marona-Lewicka,
Medhane G. Cumbay,
Val J. Watts,
Eric L. Barker, and
David E. Nichols
[Full Article -
PDF]
| |
4711-4720
Formaldehyde-Induced Alkylation of a 2'-Aminoglucose Rebeccamycin Derivative to Both A·T and G·C Base Pairs in DNA
Christian Bailly,
Jean-François Goossens,
William Laine,
Fabrice Anizon,
Michelle Prudhomme,
Jinsong Ren, and
Jonathan B. Chaires
[Full Article -
PDF]
| |
BOOK REVIEWS
|
4721-4721
Chemists at War. Accounts of Chemical Research in the United States During World War II By William A. Remers. Clarice Publications, Tucson, AZ. 2000. 216 pp. 13.5 × 16 cm. ISBN 0-9677940-0-5. $14.95 (paperback).
Edward R. Atkinson
[Full Article -
PDF] | |
4721-4722
Nucleic Acids: Structures, Properties, and Functions By Victor A. Bloomfield, Donald M. Crothers, and Ignacio Tinoco, Jr., with contributions from John E. Hearst, David E. Wemmer, Peter A. Kollman, and Douglas H. Turner. University Science Books, Sausalito, CA. 2000. ix + 794 pp. 17 × 25 cm. ISBN 0-935702-49-0. $85.00.
Sean Michael Kerwin
[Full Article -
PDF] | |
ADDITIONS AND CORRECTIONS
|
4723-4723
QSAR Model for Drug Human Oral Bioavailability.
Fumitaka Yoshida and
John G. Topliss:
[Full Article -
PDF] | |
4724-4724
3,5-Disubstituted-4-hydroxyphenyls Linked to 3-Hydroxy-2-methyl-4(1H)-pyridinone: Potent Inhibitors of Lipid Peroxidation and Cell Toxicity.
David Bebbington,
Nathaniel J. T. Monck,
Suneel Gaur,
Alan M. Palmer,
Karen Benwell,
Victoria Harvey,
Craig S. Malcolm, and
Richard H. P. Porter:
[Full Article -
PDF] | |